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By Manfred Zierhut, Hans-Georg Rammensee, Wayne Streilein
In recent times the significance of antigen-presenting cells and their effect at the eyes has been elucidated. we now have discovered that almost each constitution of the attention harbors those cells, but they range of their actions and hence within the ways that they safeguard opposed to - or perform - ailments of the attention. Antigen-Presenting Cells and the attention summarizes present wisdom approximately ACPs normally, and their position within the eye, particularly.
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Moreover, there are multiple mechanisms for peripheral tolerance induction and the different models of peripheral tolerance may share some but not all the mechanisms of regulation for an unwanted immune response. During the adult life, active suppression of immune responses may be mediated by apoptosis, T-cell energy, or the development of T regulatory cells (Tregs) (16). The CD4+ Tregs are reported both as being antigen specific and non-specific (17,18) but most reports of the CD8+ Tregs are antigen specific.
Peripheral tolerance induction: lessons from immune privileged sites and tissues. Transplant Proc 1996; 28: 2066–2070. Streilein JW. Ocular immune privilege: therapeutic opportunities from an experiment of nature. Nat Rev Immunol 2003; 3:878–889. Chen Y, Inobe J, Weiner HL. Induction of oral tolerance to myelin basic protein in CD8-depleted mice: both CD4+ and CD8+ cells mediate active suppression. J Immunol 1995; 155:910–916. Faunce DE, Sonoda KH, Stein-Streilein J. MIP-2 recruits NKT cells to the spleen during tolerance induction.
Negative selection of the T-cell repertoire: where and when does it occur? Immunol Rev 2006; 209:284–289. Iwasaki A, Medzhitov R. Toll-like receptor control of the adaptive immune responses. Nat Immunol 2004; 5:987–995. Cresswell P. Antigen presentation. Getting peptides into MHC class II molecules. Curr Biol 1994; 4:541–543. Rotzschke O, Falk K. Origin, structure and motifs of naturally processed MHC class II ligands. Curr Opin Immunol 1994; 6:45–51. Wilson NS, Villadangos JA. Regulation of antigen presentation and cross-presentation in the dendritic cell network: facts, hypothesis, and immunological implications.
Antigen-presenting cells and the eye by Manfred Zierhut, Hans-Georg Rammensee, Wayne Streilein