Chi-Chao Chan's Animal Models of Ophthalmic Diseases PDF

By Chi-Chao Chan

ISBN-10: 331919433X

ISBN-13: 9783319194332

ISBN-10: 3319194348

ISBN-13: 9783319194349

This publication describes experimental animal versions that mimic universal human ocular illnesses: herpetic keratitis, cataract, glaucoma, age-related macular degeneration, diabetic retinopathy, uveitis, retinitis pigmentosa, Graves’ affliction, and intraocular tumors. In conjunction, those versions mirror the variety and software of instruments used to review human disorder. global professional clinicians talk about each one version in response to their medical event and the textual content is supported by way of various photographs and diagrams. In describing the main pertinent animal versions of ophthalmic ailments, this publication might be of curiosity to ophthalmologists, imaginative and prescient researchers, fellows, citizens and scientific students.

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Extra resources for Animal Models of Ophthalmic Diseases

Example text

Opacities are first evident at the posterior pole of the lens and then nuclear sclerosis progresses and the cortex becomes highly opacified. The cataractous lens exhibits features such as swollen lens fibers, liquefaction, vacuolation, abnormal configuration, and the formation of Morgagnian droplets and eventually capsular rupture. Importantly, these complications can be prevented in the SDT rat by normalizing blood glucose with insulin treatment or pancreas transplantation. In addition, the histopathological changes of the lens were preceded by an increase in lens sorbitol content, further suggesting that the cataracts in the SDT rats are a result of sustained hyperglycemia (Sasase et al.

2004), but protein-bound NADPH in the form of zeta crystallin, which makes up 10 % of total lens protein in the guinea pig (Rao and Zigler 1990; Zigler and Rao 1991). Presumably, this along with trace amounts of molecular oxygen leads to UVA-induced generation of ROS. A similar process of UVA-induced protein ­aggregation may take place 2 Animal Models of Cataracts in the older human lens nucleus, possibly accelerating the formation of human nuclear cataract. Finally, UVA exposure has also been shown to induce cataracts in calves (Lee et al.

1999) and in vitro cataract development in pig lenses (Oriowo et al. 2001). The rabbit lens also contains high levels of the UVA-absorbing pyridine nucleotide NADH, both free and bound to l-crystallin (Giblin and Reddy 1980; Zigler and Rao 1991). Many of the rabbit studies investigate the preventive effect of contact lenses containing UV-blocking materials. These findings show that contact lenses are beneficial in protecting ocular tissues of the rabbit against harmful effects of UV light, including photokeratitis and anterior subcapsular cataract (Giblin et al.

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Animal Models of Ophthalmic Diseases by Chi-Chao Chan


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