Age-Related Macular Degeneration - download pdf or read online

By D. Virgil Alfaro III et al.

ISBN-10: 1451151691

ISBN-13: 9781451151695

Stay brand new with the newest advancements on your box with the highly-anticipated moment version of Age-Related Macular Degeneration. This finished textual content covers fresh advances in pathophysiology, prognosis, and remedy together with promising new advancements that might impact your sufferer care. Dr. Virgil Alfaro and his colleagues at Retina experts of Charleston convey you their services within the parts of easy technology, imaging, prevention, therapy, and more.

  • Learn from a popular workforce of retina surgeons who tackle all points of administration, together with anatomy, body structure, and pathophysiology; imaging of the macula in ARMD, prevention measures and therapy; and destiny instructions within the field.
  • Gain a fantastic beginning in intravenous fluorescein angiography, indocyanine eco-friendly angiography, and optical coherence tomography, in addition to antiVEGE treatment and comparable new medicines, optimizing your analysis and therapy options.
  • Understand the numerous switch within the category method of choroidal neovascular membranes in ARMD.
  • Get up to date info on treating ARMD secondary to geographic atrophy via cellphone transplantation and pharmacologic therapies.
  • Easily visualize key features of ARMD because of high quality illustrations and photographs.
  • Find the knowledge you would like fast by way of referencing person chapters that supply finished and inclusive assurance of the subject at hand.
Now with the print version, benefit from the bundled interactive publication version, supplying capsule, phone, or on-line entry to:
  • Complete content material with more desirable navigation 
  • Powerful seek instruments and clever navigation cross-links that pull effects from content material within the e-book, your notes, or even the web
  • Cross-linked pages, references, and extra for simple navigation
  • Highlighting instrument for simpler reference of key content material in the course of the text
  • Ability to take and proportion notes with neighbors and colleagues
  • Quick reference tabbing to save lots of your favourite content material for destiny use

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Extra resources for Age-Related Macular Degeneration

Sample text

Eyes of aged mice expressing human ApoE2, ApoE3, or ApoE4 and maintained on a high fat and cholesterol (HF-C) diet showed ApoE isoform–dependent pathologies of diverse severity. They develop a constellation of changes that mimic the pathology associated with human AMD such as ■■ Diffuse subretinal pigment epithelial deposits ■■ Drusenoid deposits ■■ Thickened BM ■■ Atrophy, hypopigmentation, and hyperpigmentation of the RPE Interestingly, ApoE4 mice were the most severely affected, to the point of having sometimes developed CNV.

Glycation-altered proteolysis is accounted for linking dietary GI, aging, and agerelated diseases like AMD. Not surprisingly, consuming higher GI diets was associated with over threefold higher accumulation of advanced glycation end products (AGEs) in the retina in the age-matched mice. Both incidence and severity of retinal changes aggravated with age, as older mice exhibited more thickening of the BM, more basal laminar deposits, disorganization of RPE basal infolding, and increased photoreceptor atrophy compared to 17-monthold counterparts (32).

235) used rabbits in an attempt to find an intermediate laser-induced CNV model between rodents and primates, thereby avoiding the expense and ethical issues concerning the latter. Nonetheless, rabbits exhibit significant anatomical discrepancies, as they do not have a macula and their retina vascular supply is different. The model utilized subretinal endophotocoagulation to create histologically identified CNV. Pig Another intermediate laser-induced CNV model is the pig. Saishin et al. (219) used a laser to create defects in the BM in the pig eye and establish histologic evidence of CNV in 100% of lesions.

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Age-Related Macular Degeneration by D. Virgil Alfaro III et al.

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