Advances in Molecular and Cellular Endocrinology, Vol. 1 by Derek Leroith PDF

By Derek Leroith

ISBN-10: 0762301589

ISBN-13: 9780762301584

Traditionally the sphere of endocrine study has constantly been on the vanguard of medical endeavors. The investigators of those very important breakthroughs in learn were rewarded by means of various Nobel awards. within the box of diabetes on my own, Nobel prizes were provided to researchers who came upon insulin, characterised the protein and invented radioimmunoassays utilizing insulin as a paradigm. now not strangely, biomedical researchers have consistently been attracted by way of the endocrine procedure and different comparable platforms of intercellular communique. during the last 20 years, endocrine study has constructed quickly and tailored smooth molecular and mobile biology options for its particular use. those alterations have allowed researchers within the box to keep up their side. hence, endocrine disease-related genes were characterised and mutations in those genes have helped clarify universal and much less universal endocrine issues. Our figuring out of the rules of gene expression has been significantly more advantageous through molecular suggestions. In an try to carry investigators brand new with the hot advances during this exploding box we've made up our minds to put up a chain entitled Advances in Molecular and mobile Endocrinology. the world over well-known investigators have agreed to take part and their contributions are preferred. quantity 1 has all for features of the hypothalamic-pituitary axis together with GnRH and GH gene law, molecular elements of insulin, insulin-like development elements and glucagon. moreover, experiences at the lately cloned calcium receptor and steroid receptor interactions with DNA are awarded.

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Extra info for Advances in Molecular and Cellular Endocrinology, Vol. 1

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Hematol. 23, 99-107. L. (1993). Regulation of gonadotropin-releasing hormone by protein kinases A and C in immortalized hypothalamic neurons. Endocrinology 132, 2360-2370. , & Negro-Vilar, A. (1991). Metabolism of pro-LHRH in immortalized hypothalamic neurons. Endocrinology 129, 1584-1595. , & Negro-Vilar, A. (1992). Intrinsic pulsatile secretory activity of immortalized LHRH secreting neurons. Proc. Natl. Acad. Sci. USA 89, 4149-4153. , & Orkin, S 90 (1990). Regulated expression of globin chains and the erythroid transcription factor GATA-1 during erythropoiesis in the developing mouse.

1994). Glucocorticoid receptor-mediated repression of gonadotropin-releasing hormone promoter activity in GT1 hypothalamic cell lines. Endocrinology 134, 1467-1474. L. (1995). The POU homeodomain transcription factor Oct- 1 is essential for activity of the gonadotropin-releasing hormone neuron-specific enhancer. Mol. Cell. Biol. 15, 6169-6177. , & Sharp, P. (1988). The B-cell-specific Oct-2 protein contains POU box- and homeo box-type domains. Genes & Dev. 2, 1570-1581. , & Chambon, P. (1980).

1992). Endogenous excitatory amino acids and glutamate receptor subtypes involved in the control of hypothalamic luteinizing hormone-releasing hormone secretion. Endocrinology 130, 1986-1992. M. (1994a). Nitric oxide synthesized by gonadotropin-releasing hormone neurons is a mediator of N-methyl-D-aspartate (NMDA)-induced GnRH secretion. Endocrinology 135, 1709-1712. M. (1994b). N-methyl-D-aspartate (NMDA) receptors mediate the release of gonadotropin-releasing hormone (GnRH) by NMDA in a hypothalamic GnRH neuronal cell line (GTI-1).

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Advances in Molecular and Cellular Endocrinology, Vol. 1 by Derek Leroith


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