Abnormalities in puberty : scientific and clinical advances by H.A. Delemarre-van de Waal, P.-E. Mullis PDF

By H.A. Delemarre-van de Waal, P.-E. Mullis

ISBN-10: 142371394X

ISBN-13: 9781423713944

ISBN-10: 3318011789

ISBN-13: 9783318011784

This booklet on abnormalities in puberty offers an outline at the most recent wisdom at the mechanisms of the developmental methods of puberty. even if the precise mechanisms of reawakening of the GnRH pulse generator on the onset of puberty nonetheless need to be elucidated, many genetic and environmental elements were pointed out to play an incredible position. themes mentioned in person chapters contain the endocrine and metabolic matters regarding the 'developmental starting place of grownup affliction' speculation and polycystic ovary syndrome in addition to abnormalities in GnRH controlling genes, GnRH-secreting hamartoma as a version for the onset of puberty, event at the program of GnRH analogues within the remedy of vital precocious puberty, and the psychosocial results of an early puberty. This quantity offers the paediatrician, endocrinologist, gynaecologist and physician with underlying details in addition to sensible tokens on the way to deal with a few of the stipulations of a disturbed technique of puberty.

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Animal Study IUGR Rats In timed pregnant Wistar rats, IUGR was induced by bilateral ligation of the uterine artery on day 17 of gestation according to a modified method of Wigglesworth [34]. 3 g, corresponding with Ϫ2 SDs of the mean of the weight of control pups born from sham-operated dams. Food-Restricted Rats Postnatal undernutrition was achieved by litter enlargement to 20 pups per mother from day 2 after birth until weaning (24 days). During lactation and postweaning, pups of all groups received a normal diet (20% protein).

5 years in SGA boys were comparable to AGA boys. CA/PA ϫ 100%, however, was Ͼ100 in SGA boys indicating that a certain pubertal stage was reached relatively late for their calendar age. Animal studies also show a delayed onset of puberty in IUGR male rats [41]. The clinical relevance of such delay is not known yet. However, an association between male gonadal dysfunction and severely reduced fetal growth has been long recognized [50, 51]. Recently, Francois et al. [52] demonstrated that unexplained male subfertility is associated with low birth weight.

In the human female associations have been found between IUGR, insulin resistance and PCO [56–58]. In analogy with our findings in the rat, the prevalence of PCO is dependent on age among women: its presence is significantly higher among women at ages younger than 35 than among older women [59]. When PCO patients become older and hence cohort size decreases with age, a considerable number of these women restore their menstrual cycle regularity. The results in the FR female rat with respect to gonadal function support the findings of others that at least partially, the fundamental defect of PCO might be a consequence of (third trimester) intra-uterine growth retardation in the human female [19, 60].

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Abnormalities in puberty : scientific and clinical advances by H.A. Delemarre-van de Waal, P.-E. Mullis


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